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KMID : 1161420160190030228
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Journal of Medicinal Food
2016 Volume.19 No. 3 p.228 ~ p.237
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The Natural Substance MS-10 Improves and Prevents Menopausal Symptoms, Including Colpoxerosis, in Clinical Research
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Noh Yoo-Hun
Kim Do-Hee
Lee Seung-Ah
Yin Xing Fu
Park Ji-Ae
Lee Moo-Yeol
Lee Won-Bok
Lee Sang-Hyung
Kim Jae-Kwang
Kim Sung-Su
Jeong Yoon-Hwa
Myung Soon-Chul
Kim Tae-Jin
Kang Il-Jun
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Abstract
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Many natural substances were screened to develop nutraceuticals that reduce menopausal symptoms. A complex of Cirsium japonicum var. maackii and Thymus vulgaris extracts, named MS-10, had significant positive effects. Under a low concentration of estrogen, which represents postmenopausal physiological conditions, MS-10 had beneficial effects on estrogen receptor-expressing MCF-7 cells by reversibly enhancing estrogen activity. In addition, in the ovariectomized rat model, changes in bone-specific alkaline phosphatase activity and osteocalcin, as well as low-density lipoprotein cholesterol and triglyceride levels were significantly decreased by MS-10. These results show that MS-10 protected bone health and reduced metabolic disturbances. Furthermore, in a clinical study, all menopausal symptoms, including hot flushes, parenthesis, insomnia, nervousness, melancholia, vertigo, fatigue, rheumatic pain, palpitations, formication, and headache, as well as colpoxerosis, were significantly improved by taking MS-10 for 90 days. Therefore, the evidence supports that MS-10 is an effective natural substance that can safely improve menopausal symptoms, including colpoxerosis.
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KEYWORD
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colpoxerosis, Kupperman's Index, MS-10, menopause, ovariectomized rat
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